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KMID : 0939920120440010032
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대한암학회지
2012 Volume.44 No. 1 p.32 ~ p.36
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Prognostic Impact of Polymorphisms in the CASPASE Genes on Survival of Patients with Colorectal Cancer
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Choi Jun-Young
Kim Jong-Gwang
Lee You-Jin
Chae Yee-Soo
Sohn Sang-Kyun
Moon Joon-Ho
Kang Byung-Woog
Jung Min-Kyu
Jeon Seong-Woo
Park Jun-Seok
Choi Gyu-Seog
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Abstract
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Purpose: This study analyzed potentially functional polymorphisms in CASPASE (CASP) genes and their impact on the prognosis for Korean colorectal cancer patients.
Materials and Methods : A total of 397 consecutive patients with curatively resected colorectal adenocarcinoma were enrolled in this study. Genomic DNA from these patients was extracted from fresh colorectal tissue, and the 10 polymorphisms in the CASP3,CASP6,CASP7,CASP8,CASP9, and CASP10 genes were determined using a reverse transcription polymerase chain reaction genotyping assay.
Results: The median patient age was 63 years, and 218 (54.9%) patients had colon cancer, while 179 (45.1%) patients had rectal cancer. Univariate and multivariate survival analysis including pathologic stage, patient age, differentiation, and carcinoembryonic antigen level demonstrated that these polymorphisms were not associated with either disease-free or overall survival.
Conclusion: None of the 10 polymorphisms in the CASP genes investigated in this study was found to be an independent prognostic marker for Korean patients with curatively resected colorectal cancer.
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KEYWORD
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Colorectal neoplasms, Caspases, Genetic polymorphism, Prognosis
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